The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) recently released a request for information (RFI) (NOT-HL-16-440) seeking input for an October 2018 conference that will address “international trends in cardiovascular morbidity and mortality.” The conference will celebrate the 40th anniversary of the landmark “Conference on the Declining Mortality from Coronary Heart Disease” (CHD). That conference brought together experts from epidemiology, clinical research, cardiology, and public health. Similarly, NHLBI would like to bring experts “in a broad range of fields to consider from a global perspective where we are in terms of understanding the direction, magnitude, differences, and drivers of trends in cardiovascular disease worldwide.” The RFI emphasizes that out of necessity, the proposed 2018 meeting will be transdisciplinary, stressing that the questions “about drivers of past changes and likely trajectories” cannot be realized by scientists from one disciplinary area. Responses to the RFI are due by December 31, 2016. For more information see the Notice.