The Patient-Centered Outcomes Research Institute (PCORI) and the American Heart Association (AHA) have announced a contest for researchers and clinicians to submit research questions that can help address evidence gaps to improve treatment for people with cardiovascular disease. The challenge will award four cash prizes of $5,000. Proposed hypotheses should pose questions that can be answered using comparative effectiveness research and a precision medicine approach. Entries must be submitted by October 6, 2016. More information is available on the PCORI website.