The Eunice Kennedy Shriver National Institute of Child Health and Human Development issued a Notice (NOT-HD-16-005) to alert investigators of the availability of the National Children’s Study (NCS) Vanguard Data and Sample Archive and Access System (NCS Archive). The NCS Vanguard served as a pilot for “a planned cohort study of environmental influences on child health and development.” The Vanguard pilot enrolled more than 14,000 participants in more than 5,000 families in 40 locations and followed them until 2014. It includes a collection of more than “14 million records and nearly 19,000 biological and 5,500 primary samples from which a sample repository of over 250,000 items was created.” That information is now available through the NCS Archive for “approved research projects by qualified investigators.” The initial release consists of study data from 2009 -2010. Additional data and sample availability is expected. For more information, see the NCS webpage.